Anti Allergic Drugs Ketotifen Fumarate For Antiasthmatic , Cas
Product Name: Ketotifen fumarate
FUMARATE;KETOTIFEN FUMARATE;KETOTIFEN FUMARATE
receptor;Aromatics;Heterocycles;Intermediates & Fine
Chemicals;Pharmaceuticals;Sulfur & Selenium
Compounds;Pharmaceutical raw material;SERC;Other APIs;Antiallergic
Melting point 192℃
Storage temp. Store at RT
Chemical Properties Off-White Solid
Usage : vasodilator .
Usage Antiasthmatic ; antiallergic.
Ketotifen fumarate is a kind of strong anti-allergic drugs
containing simultaneously of both tricyclic structure as well as
piperidine structure. It is characterized by both a strong
antagonism effect on histamine H1 receptor and inhibitory effect of
the release of the mediator of allergic reaction. It can inhibit
the release various kinds of mediators of mast cells, basophils and
macrophages, including the release of slow reacting substances and
other active substances. It also has antagonism effect on the
calcium ion; can inhibit the activity of phosphodiesterase;
increase the intracellular cAMP level inside mast cells.
Moreover, it can also inhibiting the chemotaxis and inflammation of
neutrophil with an effect 10 times as strong as that of
chlorpheniramine, and it also has a long duration time which is
better compared with sodium cromolyn. Ketotifen fumarate has
therapeutic effect on both Ⅰ and Ⅲ type of allergic reaction. Its
peak blood concentrations can sustain for 2 to 3 hours with a
half-life of 22 hours during which 60% goes through urinary
excretion, 40% goes through the fecal excretion. Children usually
have a faster excretion rate of it than adults. Long-term treatment
will not cause resistance. No rebound phenomenon will occur with
interruption of treatment.
It has been more than 20 years since ketotifen fumarate have been
applied to the prevention and treatment of asthma and childhood
asthma. It is a kind of drug with dual effect of both prevention
and treatment in the prevention and treatment of asthma and
childhood asthma. It should be particularly noted that ketotifen
had ever taken as the long-term controlling drug of asthma and
childhood long-term asthma and was subject to wide application in
many countries. Since the early 1980s, ketotifen fumarate had
already been applied in Western Europe, Asia, and China for the
prevention and treatment of asthma and asthma in children. But
since entering into 21st century, the annual applied amount has
decreased year by year. Because of its side effect of inhibition of
the central nervous system, its oral tablet currently has still not
approved by the FDA and thus failing to enter the US market with
only ketotifen fumarate eye drops (ZADITOR) had been approved by
the FDA in 1999. Recent studies have also shown the effectiveness
of ketotifen asthma still demands further studies. Moreover,
ketotifen fumarate has several additional advantages. First, it can
cause sleepiness of the schoolchildren and thus being able to
affect their academic performance; second, it can also do harm to
the mental development of infants and young children. Thirdly, it
is also be able to affect the metabolism of sustained-release tea
and thus negatively affecting its anti-inflammatory effects of
theophylline. For all the above points, it is not recommended by
the GINA (affiliated organization of WHO) to apply ketotifen
fumarate for the treatment and prevention of asthma and childhood
asthma. But from the perspective of clinical economics, ketotifen
fumarate is a suitable anti-allergic drug for being applied in
developing countries and rural areas for treating asthma and
childhood asthma with certain efficacy due to its relative low
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A: Yes, We manufacture bulk products in our factory located in
Jiayu, Hubei, and produce small quantity and customer synthesis
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